PRODUCTION OF WOUND-HEALING COATINGS BASED ON MIXTURES OF CERTAIN POLYSACCHARIDES

The work is devoted to studying the influence of the content of the ionogenic antibiotic cefotaxime salt on the rheological behavior and conformational-supramolecular state in solutions of mixtures of sodium salts of N-succinyl chitosan and carboxymethyl cellulose and on the sorption properties of films obtained on the basis of solutions for healing wounds of various etiologies. The expediency of using polysaccharide matrices based on chitosan and its derivatives is due to such properties of these aminopolysaccharides as compatibility with living tissues, the ability to prevent the proliferation of microorganisms, the ability to bioresorption, prolongation of the action of drugs and much more. At the same time, film samples based on individual sodium-N-succinyl chitosan do not always have satisfactory deformation and strength characteristics. The work shows that solutions of sodium salts of N-succinyl chitosan and carboxymethyl cellulose and their mixtures in the presence of cefotaxime both at relatively low concentrations (up to 0.2%) and in the region of higher concentrations (0.5-1%) are aggregated solutions of interacting macromolecules. When mixing sodium salts of N-succinyl chitosan and carboxymethyl cellulose, an increase in viscosity is observed compared to solutions of individual sodium salts of N-succinyl chitosan and carboxymethyl cellulose, and the degree of structuring of the solution depends on the content of the drug. The obtained regularities on the effect of modifying solutions of sodium N-succinyl chitosan with high-molecular modifiers of sodium carboxymethyl cellulose and on the effect of the drug content on the processes of macromolecule aggregation in the solution correlate with the regularities of water vapor sorption by films obtained from these solutions. Films obtained from solutions of polysaccharide mixtures are characterized by a limited degree of swelling in water vapor compared to films of individual sodium N-succinyl chitosan, which exhibit unlimited swelling with subsequent dissolution. At the same time, an increase in the content of the drug cefotaxime leads to a decrease in the amount of sorption by water vapor, which is due to a higher packing density. In this regard, it can be expected that the obtained regularities of the water absorption process will be reflected in the features of transport and prolongation of the release of drugs from mixed polysaccharide films.