Impact of Neoadjuvant Chemotherapy on Surgical Outcomes and Conversion to Node-Negativity in Invasive Lobular Breast Cancer: Analysis of Molecularly High-Risk Tumors by Histologic Subtype on the I-SPY2 Clinical Trial
These data demonstrate the challenges of surgical management for ILC but hold promise that molecular classification can improve treatment selection. While high genomic risk is generally less common among ILC, our findings suggest that gene expression assays in cN+ILC patients can identify a subset who may benefit from NAC.
Authors
- W. Fraser Symmans (ORCID: https://orcid.org/0000-0002-1526-184X)
- Nicolas D. Prionas (ORCID: https://orcid.org/0000-0001-5067-7077)
- Chantal R. Reyna (ORCID: https://orcid.org/0000-0001-7117-3716)
- Kayla Switalla (ORCID: https://orcid.org/0009-0007-2391-1076)
- Julia Tchou (ORCID: https://orcid.org/0000-0002-2032-1579)
- Neil K. Taunk (ORCID: https://orcid.org/0000-0002-1349-9774)
- Todd M. Tuttle (ORCID: https://orcid.org/0000-0001-6603-2062)
- M. Catherine Lee
- Nola Hylton
- Rachael Lancaster
- Judy C. Boughey (ORCID: https://orcid.org/0000-0003-3820-3228)
- Eileen P. Connolly (ORCID: https://orcid.org/0000-0001-6558-1932)
- Douglas Yee (ORCID: https://orcid.org/0000-0002-3387-4009)
- Marissa Howard-McNatt
- Rita A. Mukhtar (ORCID: https://orcid.org/0000-0001-8079-7846)
- Meena S. Moran (ORCID: https://orcid.org/0000-0002-4815-1313)
- Rebecca Shatsky (ORCID: https://orcid.org/0000-0003-2289-6234)
- Cletus A. Arciero (ORCID: https://orcid.org/0000-0002-8673-3349)
- A. Jo Chien (ORCID: https://orcid.org/0000-0003-2978-6249)
- Christina Yau (ORCID: https://orcid.org/0000-0002-1937-0859)
- Kamran A. Ahmed (ORCID: https://orcid.org/0000-0003-3331-1529)
- Claudine J. Isaacs (ORCID: https://orcid.org/0000-0002-9646-1260)
- Jane Perlmutter (ORCID: https://orcid.org/0000-0001-5008-0406)
- Lauren M. Postlewait
- Laura J. Esserman (ORCID: https://orcid.org/0000-0001-9202-4568)
- Lily Gutnik (ORCID: https://orcid.org/0000-0001-8674-7655)
- Henry M. Kuerer
- Jana Fox (ORCID: https://orcid.org/0000-0002-8526-8588)
- Candice A. M. Sauder (ORCID: https://orcid.org/0000-0001-6869-8634)
- Hope S. Rugo (ORCID: https://orcid.org/0000-0001-6710-4814)
- Katrina Dimitroff
- Velle Ladores
- Roshni Rao (ORCID: https://orcid.org/0000-0003-2798-3230)
- Laura Van't Veer
- Mehra Golshan
- Angela De Michele
Institutions
- University of Minnesota (US)
- Emory Healthcare (US)
- Montefiore Medical Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- Georgetown University (US)
- Loyola University Chicago (US)
- UC San Diego Health System (US)
- Moffitt Cancer Center (US)
- University of Alabama at Birmingham (US)
- Mayo Clinic in Florida (US)
- Gemini Computers (United States) (US)
- Wake Forest University (US)
- University of San Francisco (US)
- Columbia University (US)
- University of Pennsylvania (US)
- University of California, Davis (US)
- Philadelphia University (US)
Publication Details
- Journal
- Annals of Surgical Oncology
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1245/s10434-025-17862-0
- Citations
- 2
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Cancer Institute