Coronary Artery Disease–Based Polygenic Risk Score in Early-Onset Acute Myocardial Infarction Subtypes
PRS-CAD's association with AMI varied by subtype but not by sex in young adults, warranting caution in application.
Authors
- Anthony Philippakis (ORCID: https://orcid.org/0000-0001-6953-3794)
- Erica S. Spatz (ORCID: https://orcid.org/0000-0002-1557-7713)
- David Herrington
- Judith H. Lichtman (ORCID: https://orcid.org/0000-0001-5362-3875)
- Gail D’Onofrio (ORCID: https://orcid.org/0000-0002-3833-1871)
- Amit V. Khera (ORCID: https://orcid.org/0000-0001-6535-5839)
- Weilai Dong (ORCID: https://orcid.org/0000-0002-8376-1758)
- Jerome I. Rotter (ORCID: https://orcid.org/0000-0001-7191-1723)
- Wendy S. Post (ORCID: https://orcid.org/0000-0002-8655-5204)
- Mitsuaki Sawano (ORCID: https://orcid.org/0000-0003-2789-1758)
- Rachel P. Dreyer (ORCID: https://orcid.org/0000-0003-2861-1383)
- Stephen S. Rich (ORCID: https://orcid.org/0000-0003-3872-7793)
- César Caraballo (ORCID: https://orcid.org/0000-0002-4557-9437)
- Yuntian Liu (ORCID: https://orcid.org/0000-0001-6571-6112)
- Yuan Lu (ORCID: https://orcid.org/0000-0001-5264-2169)
- Harlan M. Krumholz (ORCID: https://orcid.org/0000-0003-2046-127X)
- Shu‐Xia Li (ORCID: https://orcid.org/0000-0003-1261-079X)
Institutions
- Broad Institute (US)
- Brigham and Women's Hospital (US)
- Yale New Haven Hospital (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- UCLA Medical Center (US)
- Yale University (US)
- Yale New Haven Health System (US)
- Harbor–UCLA Medical Center (US)
- Wake Forest University (US)
- University of Virginia (US)
Publication Details
- Journal
- JACC Advances
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1016/j.jacadv.2025.101994
- Citations
- 1
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- National Heart, Lung, and Blood Institute