Loss of Insulin-Positive Cell Clusters Precedes the Decrease in Islet Frequency and β-Cell Area in Type 1 Diabetes
Understanding the timing and nature of β-cell loss is essential for developing effective strategies to interrupt type 1 diabetes progression. Which types of islets, in terms of size and cellular composition, are lost first during disease development? Insulin-positive single cells and cell clusters are lost before large islets during disease development. Insulin-positive single cells and cell clusters might be more susceptible to destruction in type 1 diabetes.
Authors
- Amanda L. Posgai (ORCID: https://orcid.org/0000-0002-9491-0958)
- Rhonda L. Bacher (ORCID: https://orcid.org/0000-0001-5787-476X)
- MacKenzie D. Williams (ORCID: https://orcid.org/0000-0003-3473-2747)
- Irina Kusmartseva (ORCID: https://orcid.org/0000-0003-2614-0813)
- Mark A. Atkinson (ORCID: https://orcid.org/0000-0001-8489-4782)
- Gladys Ramos (ORCID: https://orcid.org/0000-0002-9838-4991)
- Clive Wasserfall (ORCID: https://orcid.org/0000-0002-3522-8932)
- Denise M. Drotar
- Martha Campbell‐Thompson (ORCID: https://orcid.org/0000-0001-6878-1235)
- Justin A. Smith
- Maigan A. Brusko (ORCID: https://orcid.org/0000-0002-4331-2202)
- S. David
- Caitlyn Luce
Institutions
- University of Florida Health (US)
- University of Florida (US)
- Florida College (US)
Publication Details
- Journal
- Diabetes
- Published
- 2025-07-24
- DOI
- https://doi.org/10.2337/db25-0326
- Citations
- 6
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 12.04
Funders
- National Institute of Allergy and Infectious Diseases
- National Institute of Diabetes and Digestive and Kidney Diseases