Establishing and Validating a Biomolecular Signature of Ischemia/Reperfusion Injury in a Porcine Pancreas Allotransplantation Model
The results provide new insights into biomolecular pathways (THBS1-IL6-MIR-21 crosstalk and hydroxymethylglutarate coenzyme A reductase-linked nuclear factor kappa B activation) linked to pancreatic IRI in porcine transplantation model. Identification and validation of some novel molecular pathway interactions in human pancreas transplantation could pave the path for potential targeted therapy in alleviating graft injury in the early phases of pancreatic IRI.
Authors
- Samrat Ray
- Trevor Reichman (ORCID: https://orcid.org/0000-0002-2303-1606)
- Francisco Calderón Novoa (ORCID: https://orcid.org/0000-0003-2637-7909)
- Catherine Parmentier (ORCID: https://orcid.org/0000-0001-5026-4344)
- Emmanuel Nogueira
- Bhranavi Arulratnam
- Masataka Kawamura (ORCID: https://orcid.org/0000-0003-1454-0588)
- Laura Martínez‐Arenas (ORCID: https://orcid.org/0000-0002-0683-8651)
- Markus Selzner (ORCID: https://orcid.org/0000-0002-4326-0887)
- Sujani Ganesh
- Christian Hobeika (ORCID: https://orcid.org/0000-0002-9592-2520)
Institutions
- University Health Network (CA)
- University of Toronto (CA)
- Toronto General Hospital (CA)
Publication Details
- Journal
- Transplantation Direct
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1097/txd.0000000000001793
- Primary Topic
- Organ Transplantation Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00