Ginsenoside Rc mitigates hippocampal neuronal damage and cognitive impairment in vascular dementia rats via the pY705-Stat3/Foxo3a and pS727-Stat3/GRIM-19 pathways
GRc exerted neuroprotective effects in VaD by targeting Stat3 and driving its dual-phosphorylation. Through the pY705-Stat3/Foxo3a and pS727-Stat3/GRIM-19 pathways, GRc alleviated hippocampal neuronal apoptosis and synaptic dysfunction, thereby improving cognitive function in VaD rats.
Authors
- Xiao‐Yuan Lian
- Zhizhen Zhang (ORCID: https://orcid.org/0000-0002-8290-3507)
- Yuying Wu
Institutions
- Zhejiang Ocean University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Ginseng Research
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1016/j.jgr.2025.07.003
- Citations
- 1
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province