Disruption of glutamine transport uncouples the NUPR1 stress-adaptation program and induces prostate cancer radiosensitivity
Our work underscores the role of Gln transporters and the NUPR1-mediated stress response in PCa cell survival, oxidative stress, mitochondrial functions, and radioresistance. Our findings provide a potential therapeutic in vivo strategy to enhance the efficacy of RT and suggest a potential synergism between the depletion of Gln transporters or NUPR1 and OXPHOS inhibition.
Authors
- Ayşe Sedef Köseer (ORCID: https://orcid.org/0000-0002-6733-9733)
- Ielizaveta Gorodetska (ORCID: https://orcid.org/0000-0002-3512-0462)
- Mechthild Krause (ORCID: https://orcid.org/0000-0003-1776-9556)
- Mirko Peitzsch (ORCID: https://orcid.org/0000-0002-2472-675X)
- Ira Skvortsova (ORCID: https://orcid.org/0000-0001-8993-611X)
- Anna Dubrovska (ORCID: https://orcid.org/0000-0002-3375-1500)
- Uğur Kahya (ORCID: https://orcid.org/0000-0002-3708-8806)
- Vasyl Lukiyanchuk
- Steffen Löck (ORCID: https://orcid.org/0000-0002-7017-3738)
- Dragana Savic (ORCID: https://orcid.org/0000-0001-5196-4676)
- Annett Linge (ORCID: https://orcid.org/0000-0001-9636-1721)
- Matthias M Weigel
- Berke Alkan
Institutions
- Izmir Institute of Technology (TR)
- Innsbruck Medical University (AT)
- German Cancer Research Center (DE)
- Universität Innsbruck (AT)
- Heidelberg University (DE)
- Helmholtz-Zentrum Dresden-Rossendorf (DE)
- University Hospital Heidelberg (DE)
- Tyrolean Cancer Research Institute (AT)
- National Center for Tumor Diseases (DE)
- OncoRay (DE)
- University Hospital Carl Gustav Carus (DE)
- Technische Universität Dresden (DE)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1186/s12964-025-02344-3
- Citations
- 2
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung