Genomic and Epigenomic ctDNA Profiling in Liquid Biopsies from Heavily Pretreated Patients with DNA Damage Response–Deficient Tumors
This study showcases the genomic complexity of DDR-altered tumors as revealed through baseline ctDNA profiling, an understanding of which is crucial for the future clinical development of novel DDR-directed therapies and combinations.
Authors
- Elisa Fontana (ORCID: https://orcid.org/0000-0002-4991-9355)
- Elizabeth K. Lee (ORCID: https://orcid.org/0000-0001-7533-7853)
- Paul Basciano
- Benjamin Herzberg (ORCID: https://orcid.org/0000-0002-3253-3106)
- Ian M. Silverman (ORCID: https://orcid.org/0000-0003-3819-6726)
- Stéphanie Lheureux (ORCID: https://orcid.org/0000-0003-4405-5890)
- Michael J. Zinda (ORCID: https://orcid.org/0009-0002-1394-2032)
- Patrick C. Fiaux (ORCID: https://orcid.org/0000-0001-9614-7370)
- Michael Cecchini (ORCID: https://orcid.org/0000-0003-3504-0128)
- Insil Kim
- Joseph D. Schonhoft (ORCID: https://orcid.org/0000-0002-5860-5040)
- Timothy Anthony Yap (ORCID: https://orcid.org/0000-0002-2154-3309)
- Sunantha Sethuraman (ORCID: https://orcid.org/0000-0003-2636-5983)
- Benedito A. Carneiro (ORCID: https://orcid.org/0000-0002-5468-1126)
- Errin Lagow
- Victoria Rimkunas (ORCID: https://orcid.org/0000-0003-4263-2009)
- Jorge S. Reis‐Filho (ORCID: https://orcid.org/0000-0003-2969-3173)
- Ezra Y. Rosen (ORCID: https://orcid.org/0000-0002-5289-1541)
- Pegah Safabakhsh
- Danielle Ulanet (ORCID: https://orcid.org/0009-0001-7754-9224)
- Arielle Yablonovitch (ORCID: https://orcid.org/0000-0001-6339-4519)
- Julia Yang
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- Sarah Cannon Research Institute (GB)
- Brown University (US)
- Columbia University Irving Medical Center (US)
- Princess Margaret Cancer Centre (CA)
- Yale University (US)
- Guardant (United States) (US)
- Dana-Farber Cancer Institute (US)
- AstraZeneca (United States) (US)
- Xilio Therapeutics (United States) (US)
- New York University (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-1248
- Citations
- 1
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Amgen
- Pfizer
- AstraZeneca
- Novocure
- Revolution Medicines
- MacroGenics
- Seagen
- Eisai
- Astellas Pharma
- National Cancer Institute
- Daiichi Sankyo Europe