The Impact of Low-Lactose, High Galacto-Oligosaccharides Milk on Gut Microbiome and Plasma Metabolome in Healthy Adults: A Randomized, Double-Blind, Controlled Clinical Trial Complemented by Ex Vivo Experiments
N milk resulted in a significant increase in gut bifidobacteria, along with changes in plasma metabolites previously associated with immune and metabolic health benefits.This study was registered at clinicaltrials.gov as NCT05207839.
Authors
- Maria Pilar Giner
- Chieh Jason Chou (ORCID: https://orcid.org/0000-0002-8291-517X)
- Anirban Lahiry (ORCID: https://orcid.org/0009-0008-9191-0136)
- Stefan Christen (ORCID: https://orcid.org/0000-0002-2121-8215)
- Léa Siegwald (ORCID: https://orcid.org/0000-0001-6464-687X)
- Francis Foata
- Anna Cherta-Murillo (ORCID: https://orcid.org/0000-0002-2482-9898)
- Olga Sakwińska (ORCID: https://orcid.org/0000-0002-3142-9542)
- Adrien Frézal
- Claire L. Boulangé (ORCID: https://orcid.org/0000-0002-9022-0159)
- Jean-Philippe Godin
Institutions
- Nestlé (Switzerland) (CH)
Publication Details
- Journal
- Current Developments in Nutrition
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1016/j.cdnut.2025.107506
- Citations
- 1
- Primary Topic
- Digestive system and related health
- Type
- article
- Field-Weighted Citation Impact
- 1.82