Soluble Oncoimmunome Signatures Predict Muscle Mass Response to Enriched Immunonutrition in Cancer Patients: Subanalysis of a Multicenter Randomized Clinical Trial
Our findings support the use of enriched oral nutritional supplementation (ONS) as an effective strategy not only to enhance caloric and protein intake but also to promote anabolism and preserve muscle mass in cancer patients. The identification of immune profiles suggests that specific biomarkers could be used to predict which patients will benefit most from this type of intervention. This may allow for the implementation of personalized immunonutrition strategies that optimize resource allocation and improve clinical outcomes, particularly in vulnerable populations at risk of cachexia.
Authors
- Olatz Izaola (ORCID: https://orcid.org/0000-0003-1201-4875)
- Antonio Jesús Martínez-Ortega (ORCID: https://orcid.org/0000-0002-2878-4017)
- Alan Calleja
- Sara Cuesta‐Sancho (ORCID: https://orcid.org/0000-0002-9890-1063)
- David Primo (ORCID: https://orcid.org/0000-0002-3474-0766)
- Daniel Antonio de Luis (ORCID: https://orcid.org/0000-0002-1745-9315)
- Pedro Pablo García‐Luna (ORCID: https://orcid.org/0000-0001-7460-5422)
- David Bernardo (ORCID: https://orcid.org/0000-0002-2843-6696)
- Juan José López Gómez (ORCID: https://orcid.org/0000-0003-3144-343X)
- Tamara Casañas
Institutions
- Universidad de Valladolid (ES)
- Universidad de Las Palmas de Gran Canaria (ES)
- Centro de Investigación Biomédica en Red (ES)
- Instituto de Biomedicina y Genética Molecular de Valladolid (ES)
- Hospital Universitario Virgen del Rocío (ES)
- Hospital Clínico Universitario de Valladolid (ES)
Publication Details
- Journal
- Nutrients
- Published
- 2025-07-24
- DOI
- https://doi.org/10.3390/nu17152421
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Junta de Castilla y León