Engineered Glibenclamide-Loaded Nanovectors Hamper Inflammasome Activation in an Ex Vivo Alzheimer’s Disease Model—A Novel Potential Therapy for Neuroinflammation: A Pilot Study
All together, these results showed that GNV is able to dampen inflammation and NLRP-3 inflammasome activation in an ex vivo monocyte model, suggesting a possible role for GNV in controlling AD-associated neuroinflammation.
Authors
- Ivana Marventano
- Francesca La Rosa (ORCID: https://orcid.org/0000-0003-3181-9505)
- Federica Piancone (ORCID: https://orcid.org/0000-0001-7951-1169)
- Federica Rossetto (ORCID: https://orcid.org/0000-0001-6336-2648)
- Marina Saresella (ORCID: https://orcid.org/0000-0002-2295-3043)
- Ambra Hernis (ORCID: https://orcid.org/0000-0001-9234-6452)
- Arianna Amenta (ORCID: https://orcid.org/0000-0001-9111-9768)
- Silvia Sesana (ORCID: https://orcid.org/0000-0002-6651-9468)
- Jorge Navarro (ORCID: https://orcid.org/0000-0003-1508-6727)
- Roberta Mancuso (ORCID: https://orcid.org/0000-0002-4449-3623)
- Elisabetta Bolognesi (ORCID: https://orcid.org/0000-0001-5554-1697)
- Pietro Davide Trimarchi (ORCID: https://orcid.org/0000-0003-3282-5261)
- Francesca Re (ORCID: https://orcid.org/0000-0003-1374-567X)
- Mario Clerici (ORCID: https://orcid.org/0000-0001-5920-6191)
- Pierfausto Seneci (ORCID: https://orcid.org/0000-0001-9709-7344)
- Franca Rosa Guerini (ORCID: https://orcid.org/0000-0001-9461-5927)
- Simone Agostini (ORCID: https://orcid.org/0000-0002-6214-0645)
- Lorenzo Agostino Citterio (ORCID: https://orcid.org/0000-0002-5218-0475)
Institutions
- University of Milan (IT)
- Don Carlo Gnocchi Foundation (IT)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Biomolecules
- Published
- 2025-07-24
- DOI
- https://doi.org/10.3390/biom15081074
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute
- Fondazione Romeo ed Enrica Invernizzi