Genetic architecture of hypertrophic cardiomyopathy in individuals of Chinese and United Kingdom ancestry
Our findings suggested that patients of Chinese ancestry with HCM have a higher proportion of rare variants but are less likely to be classified as P/LP variants in HCM genes than those of European origin. The variants of c.3624del in <i>MYBPC3</i> and c.300C > G in <i>TNNT2</i> were specific to Chinese individuals and provide important insights into the ethnic differences of HCM genetic architecture.
Authors
- Yongsan Yang
- Jiajun Guo (ORCID: https://orcid.org/0000-0003-4379-2661)
- Jinquan Zhang (ORCID: https://orcid.org/0000-0001-8211-0374)
- Yuchi Han (ORCID: https://orcid.org/0000-0001-7582-1848)
- Dominic Russ (ORCID: https://orcid.org/0000-0002-2705-2068)
- Georgios V. Gkoutos (ORCID: https://orcid.org/0000-0002-2061-091X)
- Jie Wang (ORCID: https://orcid.org/0000-0001-7505-3850)
- Yucheng Chen (ORCID: https://orcid.org/0000-0001-8480-4054)
- Heng Xu (ORCID: https://orcid.org/0000-0002-7748-2621)
- Yuanwei Xu (ORCID: https://orcid.org/0000-0002-2337-3999)
- Mengdi Yu
- Lutong Pu (ORCID: https://orcid.org/0009-0009-7514-1514)
- Ke Wan (ORCID: https://orcid.org/0000-0002-6194-0392)
Institutions
- Sichuan University (CN)
- West China Medical Center of Sichuan University (CN)
- The Ohio State University Wexner Medical Center (US)
- University College Birmingham (GB)
- West China Hospital of Sichuan University (CN)
- Health Data Research UK (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- Precision Clinical Medicine
- Published
- 2025-06-28
- DOI
- https://doi.org/10.1093/pcmedi/pbaf019
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Sichuan University
- Natural Science Foundation of Sichuan Province
- West China Hospital, Sichuan University