Randomized Trial of Dapagliflozin in Patients With Nondiabetic Stage 4 CKD
Dapagliflozin safely ameliorates (compensatory) glomerular hyperfiltration and proteinuria and is glycosuric in nondiabetic patients with preterminal CKD. GFR reduction is likely because of postglomerular vasodilation rather than preglomerular vasoconstriction.
Authors
- Matias Trillini (ORCID: https://orcid.org/0000-0003-1859-1729)
- Sandro Sironi (ORCID: https://orcid.org/0000-0002-4469-5073)
- Paola Boccardo (ORCID: https://orcid.org/0000-0003-4969-6187)
- Nadia Rubis (ORCID: https://orcid.org/0000-0003-4568-1295)
- Anna Caroli (ORCID: https://orcid.org/0000-0002-4130-4663)
- Alessandro Villa (ORCID: https://orcid.org/0000-0001-5556-5701)
- Francesco Peraro (ORCID: https://orcid.org/0000-0002-5569-5300)
- Giovanni Giuliano (ORCID: https://orcid.org/0000-0002-2486-0510)
- Dominique Cadé
- Sara Gamba (ORCID: https://orcid.org/0000-0002-4887-890X)
- Andrea Remuzzi (ORCID: https://orcid.org/0000-0002-4301-8927)
- SL Borchetto
- Giulia Gherardi
- Silvia Prandini (ORCID: https://orcid.org/0000-0001-9337-9512)
- Elena Perticucci
- F Gregis
- Fabiola Carrara (ORCID: https://orcid.org/0000-0002-5799-9535)
- Erica Daina (ORCID: https://orcid.org/0000-0002-2419-5493)
- Daniela Cugini (ORCID: https://orcid.org/0000-0002-0764-6029)
- Antonio Nicola Cannata (ORCID: https://orcid.org/0000-0001-7609-6297)
- Flavio Gaspari (ORCID: https://orcid.org/0000-0001-5941-3481)
- Annalisa Perna (ORCID: https://orcid.org/0000-0002-9257-0283)
- S. Peracchi
- Erika Diani (ORCID: https://orcid.org/0000-0001-5748-7743)
- Alessia Gennarini
- Nadia Stucchi (ORCID: https://orcid.org/0000-0002-3739-2373)
- Paolo Brambilla (ORCID: https://orcid.org/0000-0002-4021-8456)
- Rosa Caruso (ORCID: https://orcid.org/0009-0002-2273-9327)
- Tiziano Gamba
- Davide Martinetti (ORCID: https://orcid.org/0000-0001-5839-1612)
- Vincenzo Gambara
- Norberto Perico (ORCID: https://orcid.org/0000-0002-3147-4327)
- Elena Bresin (ORCID: https://orcid.org/0000-0003-4198-2891)
- V. Lecchi (ORCID: https://orcid.org/0000-0001-6528-0857)
- Tobia Peracchi (ORCID: https://orcid.org/0000-0001-5312-7644)
- B Taddei
- Diego Fidone (ORCID: https://orcid.org/0009-0009-4469-6058)
- Silvia Ferrari (ORCID: https://orcid.org/0000-0003-0769-0414)
- Giulia Villa (ORCID: https://orcid.org/0000-0003-1120-9638)
- Davide Villa (ORCID: https://orcid.org/0000-0002-9823-7692)
- Piero Ruggenenti
- Stefano Rota
- Valentina Leone
- Antonio Chiappa
- Chiara Guarinoni
- Francesca Abbadini
- Jennifer Piffari
Institutions
- Mario Negri Institute for Pharmacological Research (IT)
- Ospedale Papa Giovanni XXIII (IT)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1016/j.ekir.2025.07.020
- Citations
- 1
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.29