A step forward in pediatric hemophagocytic lymphohistiocytosis and autoimmune disease: pediatric reference interval for serum soluble IL-2 receptor and soluble CD163
This study provides comprehensive pediatric RIs for serum sIL-2R and sCD163 to support clinical decision-making in HLH and related inflammatory disorders. The stability of both sIL-2R and sCD163 under diverse conditions supports their reliable use in clinical settings. These findings may facilitate broader clinical implementation, pending on local validation and standardization.
Authors
- Mia Elbek Schjørring (ORCID: https://orcid.org/0009-0002-6614-857X)
- Tina Parkner (ORCID: https://orcid.org/0009-0007-2351-7431)
- Anne Winther‐Larsen (ORCID: https://orcid.org/0000-0002-2763-595X)
- Holger Jon Møller (ORCID: https://orcid.org/0000-0001-7687-5995)
- Cindy Soendersoe Knudsen
- Victor Bruun (ORCID: https://orcid.org/0009-0004-0952-6807)
Institutions
- Aarhus University (DK)
- Aarhus University Hospital (DK)
Publication Details
- Journal
- Clinical Chemistry and Laboratory Medicine (CCLM)
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1515/cclm-2025-0653
- Citations
- 1
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 1.77