Persistent inflammation and white matter damage in the preterm brain: Insights from a novel ovine model of chronic inflammation
We demonstrated that in a large animal model of inflammation-induced intrauterine preterm brain injury, long-term persistent inflammation occurs, along with significant white matter injury, including loss of oligodendrocytes and reduced myelination in multiple white matter regions. This model paves the way for long-term evaluation of promising therapeutics and behavioral assessment in this clinically relevant model of persistent preterm brain injury.
Authors
- Amy E. Sutherland (ORCID: https://orcid.org/0000-0002-4807-2340)
- Tamara Yawno (ORCID: https://orcid.org/0000-0002-4257-3814)
- Charmaine R. Rock (ORCID: https://orcid.org/0000-0003-4719-4175)
- Ilias Nitsos
- Lindsay Zhou (ORCID: https://orcid.org/0000-0002-3013-5040)
- Rod W. Hunt (ORCID: https://orcid.org/0000-0002-2446-1739)
- Beth J. Allison (ORCID: https://orcid.org/0000-0002-1060-513X)
- Abdul Razak (ORCID: https://orcid.org/0000-0002-6185-3694)
- Stephanie Miller (ORCID: https://orcid.org/0000-0002-0451-8304)
- Tegan A. White (ORCID: https://orcid.org/0000-0001-8809-3448)
- Courtney McDonald (ORCID: https://orcid.org/0000-0001-8421-461X)
- Yen Pham
- Anil K. Malhotra (ORCID: https://orcid.org/0000-0001-9664-4182)
Institutions
- Hudson Institute of Medical Research (AU)
- Monash Children’s Hospital (AU)
- Monash Institute of Medical Research (AU)
Publication Details
- Journal
- Experimental Neurology
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1016/j.expneurol.2025.115397
- Citations
- 2
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 6.99