A preliminary report on the feasibility of regression-based alignment of diagnostic thresholds for harmonized use of international classification criteria for antiphospholipid syndrome
The regression-based conversion of diagnostic thresholds is practical in harmonizing diagnostic classification across major aPL assays. The specificity-based method may need adjusted predefined-specificities to estimate thresholds that are equivalent to the traditional thresholds.
Authors
- Junzo Nojima (ORCID: https://orcid.org/0000-0003-4720-015X)
- Yuichiro Fujieda (ORCID: https://orcid.org/0000-0003-4705-341X)
- Kiyoshi Ichihara (ORCID: https://orcid.org/0000-0002-6039-4537)
- Eriko Morishita (ORCID: https://orcid.org/0000-0001-9116-3363)
- Risa Kaneshige (ORCID: https://orcid.org/0000-0001-7255-4705)
- Kenji Oku (ORCID: https://orcid.org/0000-0003-0790-665X)
- Masahiro Ieko (ORCID: https://orcid.org/0000-0003-1854-4543)
- Tatsuya Atsumi (ORCID: https://orcid.org/0000-0001-5657-962X)
- Yukari Motoki (ORCID: https://orcid.org/0000-0002-0509-8364)
Institutions
- Kanazawa University (JP)
- Tokai University (JP)
- Kanazawa Medical University (JP)
- Yamaguchi University (JP)
- Sapporo University (JP)
- Hokkaido University (JP)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1371/journal.pone.0328229
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science