Serum 25(OH)D levels and mortality risk among middle-aged and elderly populations in the U.S.: A prospective cohort study
This study found that higher serum 25-hydroxyvitamin D concentrations are linked to lower all-cause, cardiovascular, and cancer mortality. The relationship is nonlinear: increases in concentration reduce death risk below a certain threshold, but above it, the association weakens. Further research is needed to understand causal mechanisms.
Authors
- Faliang Gao (ORCID: https://orcid.org/0000-0002-8170-2156)
- Wenyan Zhao (ORCID: https://orcid.org/0000-0002-2222-377X)
- Huibo He
- Xiaopeng He (ORCID: https://orcid.org/0009-0003-9521-6807)
- Yuan Yang (ORCID: https://orcid.org/0009-0000-9410-9979)
- Xi Chen (ORCID: https://orcid.org/0009-0001-5818-600X)
- Wei Yang
- Yujie Zhao (ORCID: https://orcid.org/0000-0001-9317-3717)
- Yaowen Hu (ORCID: https://orcid.org/0000-0002-9979-0318)
- Jie Zhou (ORCID: https://orcid.org/0009-0004-6063-6358)
Institutions
- Hangzhou Medical College (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1371/journal.pone.0328907
- Citations
- 2
- Primary Topic
- Vitamin D Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Zhejiang Traditional Chinese Medicine Administration
- Science and Technology Program of Zhejiang Province