Retrospective study of definitive therapy for head and neck mucosal melanoma: The RESUME study

<h2>Abstract</h2><h3>Background</h3> Head and neck mucosal melanoma (HNMM) is a rare melanoma. Surgery and radiotherapy (RT) are commonly used; however, their effectiveness remains unclear. In addition, the role of immune checkpoint inhibitors (ICIs) in improving survival in patients with locally advanced HNMM has not been fully evaluated. <h3>Patients and methods</h3> This multi-institutional retrospective cohort study analyzed patients with locally advanced HNMM who were treated within the period October 2014 to March 2022. Patients either underwent surgery (S cohort) or received RT (RT cohort). Progression-free survival (PFS) and overall survival (OS) were compared between the S and RT cohorts and between those with and without ICI using propensity score-adjusted models. <h3>Results</h3> A total of 304 patients were enrolled: 152 in the S cohort and 152 in the RT cohort. After matching, no significant differences in PFS and OS were observed between the S and RT cohorts. The addition of ICI was associated with significantly improved PFS (hazard ratio 0.50, 95% confidence interval 0.32-0.80), with a favorable but nonsignificant trend in OS. Subgroup analysis showed that ICI was associated with prolonged OS in the S cohort but had no statistically significant effect in the RT cohort. Disease progression was predominantly distant, irrespective of treatment modality. <h3>Conclusion</h3> Surgery and RT were associated with comparable survival outcomes for locally advanced HNMM. ICI was associated with PFS, but its relationship with OS needs further investigation. Prospective and randomized studies are needed to refine treatment approaches for this rare malignancy.

Authors

Institutions

Publication Details

Journal
EJC Skin Cancer
Published
2025-01-01
DOI
https://doi.org/10.1016/j.ejcskn.2025.100736
Citations
1
Primary Topic
Cutaneous Melanoma Detection and Management
Type
article
Field-Weighted Citation Impact
1.05
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Retrospective study of definitive therapy for head and neck mucosal melanoma: The RESUME study

Akira Ohkoshi, Nayuta Tsushima, Takashi Mukaigawa, Kiyoto Shiga et al.
1 citations
EJC Skin Cancer
Cutaneous Melanoma Detection and Management
1.05
article

Retrospective study of definitive therapy for head and neck mucosal melanoma: The RESUME study

Akira Ohkoshi, Nayuta Tsushima, Takashi Mukaigawa, Kiyoto Shiga, Hisayuki Kato, Yosuke Ariizumi, Soichi Fumita, Naoki Nishio, Mutsukazu Kitano, Naomi Kiyota, Morimasa Kitamura, Nobuhiko Oridate, Shujiro Minami, Nobuhiro Hanai, Yuki Saito, Yasushi Shimizu, Takenori Ogawa, Yasushi Fujimoto, Taiji Koyama, Atsushi Motegi, Kenji Okami, Shigeyuki Murono, Mioko Matsuo, Junichiro Ohori, Akihiro Homma, Motoo Nomura, Tetsuo Akimoto, Daisuke Kawakita, Tsutomu Ueda, Mitsuhiko Nakahira, Stephen Y. D. To, Takashi Fujii, Kiyoaki Tsukahara, Hiroki Mitani
article en
1 citations

Abstract

<h2>Abstract</h2><h3>Background</h3> Head and neck mucosal melanoma (HNMM) is a rare melanoma. Surgery and radiotherapy (RT) are commonly used; however, their effectiveness remains unclear. In addition, the role of immune checkpoint inhibitors (ICIs) in improving survival in patients with locally advanced HNMM has not been fully evaluated. <h3>Patients and methods</h3> This multi-institutional retrospective cohort study analyzed patients with locally advanced HNMM who were treated within the period October 2014 to March 2022. Patients either underwent surgery (S cohort) or received RT (RT cohort). Progression-free survival (PFS) and overall survival (OS) were compared between the S and RT cohorts and between those with and without ICI using propensity score-adjusted models. <h3>Results</h3> A total of 304 patients were enrolled: 152 in the S cohort and 152 in the RT cohort. After matching, no significant differences in PFS and OS were observed between the S and RT cohorts. The addition of ICI was associated with significantly improved PFS (hazard ratio 0.50, 95% confidence interval 0.32-0.80), with a favorable but nonsignificant trend in OS. Subgroup analysis showed that ICI was associated with prolonged OS in the S cohort but had no statistically significant effect in the RT cohort. Disease progression was predominantly distant, irrespective of treatment modality. <h3>Conclusion</h3> Surgery and RT were associated with comparable survival outcomes for locally advanced HNMM. ICI was associated with PFS, but its relationship with OS needs further investigation. Prospective and randomized studies are needed to refine treatment approaches for this rare malignancy.

EJC Skin CancerVol. 3
Kagoshima University (JP), Hiroshima University (JP), Tokyo Institute of Technology (JP), Fukushima Medical University (JP), Tokai University (JP), Kyushu University (JP), Fujita Health University (JP), Tokyo Medical University (JP), Aichi Medical University (JP), Kanazawa Medical University (JP), Iwate Medical University (JP), Tohoku University (JP), Hokkaido University (JP), Kyoto University (JP), Cancer Institute (WIA) (IN), Nagoya City University (JP), Tokyo Institute of Psychiatry (JP), Shizuoka Cancer Center (JP), Kobe University Hospital (JP), National Hospital Organization Kyushu Cancer Center (JP), Tokyo Medical Center (JP), Yokohama City University Hospital (JP), University of Tokyo Hospital (JP), Nara Medical University Hospital (JP), Aichi Cancer Center (JP), National Cancer Center Hospital East (JP), Kyoto University Hospital (JP), Osaka International Cancer Institute (JP), Gifu University (JP), Japanese Foundation For Cancer Research (JP), Nagoya University (JP), Saitama Medical University (JP), Yokohama City University (JP), Kindai University (JP)
Zero hunger
Openalex Percentile: Top 19%
Cutaneous Melanoma Detection and Management
1.05
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.