A novel SPECT-CT imaging platform for quantifying <i>in vivo</i> lung cytokine signals in COPD
We report novel analysis techniques for molecular imaging of the human lung, presenting a platform which provides new insights into complex inflammatory disease and future precision medicine approaches.
Authors
- Doriana Cellura
- Anna Chilcott
- Maria G. Belvisi (ORCID: https://orcid.org/0000-0003-1652-4370)
- Clint Zvavamwe
- Karl J. Staples (ORCID: https://orcid.org/0000-0003-3844-6457)
- C. Mirella Spalluto (ORCID: https://orcid.org/0000-0001-7273-0844)
- Aiman Alzetani (ORCID: https://orcid.org/0000-0002-3373-6714)
- Francis Sundram
- Kristoffer Ostridge (ORCID: https://orcid.org/0000-0001-8910-3900)
- Michael J. Bennett (ORCID: https://orcid.org/0000-0002-2930-4900)
- Benjamin Welham (ORCID: https://orcid.org/0000-0001-9683-252X)
- Alex Kong
- Darren Henley
- Aishath Fazleen (ORCID: https://orcid.org/0000-0002-1286-9374)
- Peter M. Lackie (ORCID: https://orcid.org/0000-0001-7138-3764)
- Emily Shaw
- Paul H. Lee (ORCID: https://orcid.org/0000-0002-5729-6450)
- Sandra Johns
- Adam Platt (ORCID: https://orcid.org/0009-0008-0109-7699)
- Christopher McCrae (ORCID: https://orcid.org/0000-0001-7184-9069)
- Matthew Guy (ORCID: https://orcid.org/0000-0002-6818-2010)
- Tom Wilkinson (ORCID: https://orcid.org/0000-0003-1771-3851)
- Matthew Lawson (ORCID: https://orcid.org/0000-0003-0115-1698)
- Sofia Michopoulou (ORCID: https://orcid.org/0000-0003-1974-8388)
- Stephen P. Harden (ORCID: https://orcid.org/0000-0002-9995-6058)
Institutions
- AstraZeneca (United Kingdom) (GB)
- Southampton General Hospital (GB)
- University Hospital Southampton NHS Foundation Trust (GB)
- NIHR Southampton Respiratory Biomedical Research Unit (GB)
- AstraZeneca (Finland) (FI)
- AstraZeneca (Sweden) (SE)
- AstraZeneca (United States) (US)
- University of Southampton (GB)
- Imperial College London (GB)
Publication Details
- Journal
- ERJ Open Research
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1183/23120541.01246-2024
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- AstraZeneca
- Queen Mary University of London
- University Hospital Southampton NHS Foundation Trust
- University of Southampton