Synchronous Twin Malignancies in a 32-Year-Old Female: A Rare and Complex Case Report

Synchronous twin malignancies, defined as the simultaneous occurrence of two distinct primary cancers in the same patient, represent a rare and challenging clinical scenario. Synchronous diagnosis of haematological and solid malignancy poses a challenge in treatment planning. This case study details the presentation, diagnosis, treatment, and eventual outcome of a 32-year-old female with acute promyelocytic leukaemia and metastatic non-small cell lung carcinoma. The patient’s complex clinical course, including the development of pancytopenia with bleeding manifestations, therapy-related issues, and progressive disease, underscores the need for a high index of suspicion in managing such rare oncological presentations.

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Publication Details

Journal
EMJ Hematology
Published
2025-07-24
DOI
https://doi.org/10.33590/emjhematol/mrii7792
Primary Topic
Multiple and Secondary Primary Cancers
Type
article
Field-Weighted Citation Impact
0.00
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article

Synchronous Twin Malignancies in a 32-Year-Old Female: A Rare and Complex Case Report

Mahendra Kawedia, Aniket Mohite, Sulaxmi Kurade, Satyajit Pawar
EMJ Hematology
Multiple and Secondary Primary Cancers
article

Synchronous Twin Malignancies in a 32-Year-Old Female: A Rare and Complex Case Report

Mahendra Kawedia, Aniket Mohite, Sulaxmi Kurade, Satyajit Pawar
article en

Abstract

Synchronous twin malignancies, defined as the simultaneous occurrence of two distinct primary cancers in the same patient, represent a rare and challenging clinical scenario. Synchronous diagnosis of haematological and solid malignancy poses a challenge in treatment planning. This case study details the presentation, diagnosis, treatment, and eventual outcome of a 32-year-old female with acute promyelocytic leukaemia and metastatic non-small cell lung carcinoma. The patient’s complex clinical course, including the development of pancytopenia with bleeding manifestations, therapy-related issues, and progressive disease, underscores the need for a high index of suspicion in managing such rare oncological presentations.

EMJ Hematology
Jehangir Hospital (IN)
Openalex Percentile: Top 74%
Multiple and Secondary Primary Cancers
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