The role of advanced glycation end products (AGEs) and the receptor for AGEs (RAGE) in hypertrophic obstructive cardiomyopathy
Circulating RAGE appears to act as a protective biomarker, as it is associated with better prognosis after septal myectomy, reducing fibrosis and improving cardiac function in HOCM patients. It is plausible that higher circulating RAGE levels may be derived from higher expression levels in the myocardium.
Authors
- Xuanye Bi (ORCID: https://orcid.org/0000-0002-4201-1758)
- Quanxu An
- Shengxu Li (ORCID: https://orcid.org/0000-0001-9210-7283)
- Yu-Hang Li (ORCID: https://orcid.org/0000-0002-6336-5088)
- Yazhe Tang (ORCID: https://orcid.org/0000-0002-9892-1152)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fifth Affiliated Hospital of Zhengzhou University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Fu Wai Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1371/journal.pone.0328032
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00