Serum Concentration of Apixaban in Relation to Renal Function in Older Hospitalized Patients
The study shows that dose-adjusted serum concentration of apixaban significantly correlates with renal function in older, acute hospitalized patients. These real-life data indicate that apixaban-treated patients with GFR < 30 ml/min may require around 70% lower dose than normal to achieve sufficient antithrombotic effect and prevent risk of bleedings.
Authors
- Espen Molden (ORCID: https://orcid.org/0000-0001-6190-2751)
- Trude Cecilie Mellingsæter
- Ole Martin Steihaug (ORCID: https://orcid.org/0000-0002-1849-3910)
Institutions
- University of Oslo (NO)
- Deaconess Hospital (US)
- Diakonhjemmet Hospital (NO)
- Western Norway University of Applied Sciences (NO)
Publication Details
- Journal
- Drugs & Aging
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1007/s40266-025-01232-2
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Diakonhjemmet