Potential of Muntingia Calabura L. Leaf Extract Cream on the Late Remodeling Phase of Wound Healing in Diabetic Rats (Rattus Norvegicus)

Wound healing is a complex biological mechanism of the body that repairs damaged tissue by involving various cellular activities. This study aimed to determine the effectiveness of Muntingia calabura L. leaf extract cream to accelerate incision wound healing on day 21 in white rats (Rattus norvegicus) with diabetes mellitus. This experiment used 12 male white rats weighing 150-200 g and 2-3 months old, induced by a single dose of streptozotocin. The incision was made on the paravertebral area along 2 cm and a depth of 2 mm. Wound therapy was given twice a day for 21 days, P1 was given cream base and distilled water , P2 was given 0.1% silver sulfadiazine cream and metformin 4, 5 mg/k g weight, P3 and P4 were given 5% and 15% Muntingia calabura L. leaf extract cream with oral extract 450 mg/k g body weight. ANOVA test results showed a significant effect (P<0.05) on the number of fibroblasts and density of collagen. Duncan test results on fibroblast, P1 were significantly different (P<0.05) from P2, P3, and P4, while the results on density of collagen, P3 were significantly different (P<0.05) from P1, P2, and P4. Based on the results, it can be concluded that 5% Muntingia calabura L . leaf extract cream can decrease the number of fibroblasts and increase the density of collagen, which is effective in accelerating incision wound healing on day 21 on white rats' skin with diabetes mellitus.