ATUALIZAÇÕES NO TRATAMENTO DA DOENÇA DE ALZHEIMER: NOVAS PERSPECTIVAS FARMACOLÓGICAS

Alzheimer’s disease (AD) is a progressive and multifactorial neurodegenerative disorder and the leading cause of dementia among the elderly worldwide. Despite therapeutic advances, traditional treatment approaches remain largely focused on symptomatic management, offering limited impact on disease progression. In recent years, however, novel pharmacological strategies have emerged, aiming to modify key pathophysiological mechanisms underlying AD. This article reviews the most recent updates in AD treatment, with emphasis on therapies targeting the clearance of neurotoxic proteins, regulation of mitochondrial function, control of neuroinflammation, and the use of biomarkers for early diagnosis and patient stratification. The analysis of clinical and preclinical evidence suggests an ongoing paradigm shift toward more personalized, integrated, and effective interventions. Although substantial challenges remain, recent pharmacological advances point to a more promising therapeutic landscape, with the potential to transform clinical care and improve outcomes for individuals with Alzheimer’s disease.