Spatial and maturity heterogeneity of tertiary lymphoid structures shapes immune microenvironment and progression in prostate cancer
In conclusion, this study highlights the prognostic and immunological implications of TLS heterogeneity in PCa, demonstrating that the spatial distribution and maturity of TLSs are closely linked to TME activation and improved clinical outcomes. These findings provide novel insights into the immune landscape of PCa and establish a foundation for immune-based precision stratification and therapeutic development.
Authors
- Ren Mo
- W. Guo (ORCID: https://orcid.org/0000-0001-9753-9165)
- Aihetaimujiang Anwaier (ORCID: https://orcid.org/0000-0002-0859-5171)
- Dingwei Ye (ORCID: https://orcid.org/0000-0002-6761-5195)
- Qintao Ge (ORCID: https://orcid.org/0000-0001-5040-6699)
- Xi Tian (ORCID: https://orcid.org/0000-0003-1965-0647)
- Chuanhai Cai
- Jiahe Lu (ORCID: https://orcid.org/0000-0002-3555-1991)
- Hailiang Zhang (ORCID: https://orcid.org/0000-0002-8050-2494)
- Wenhao Xu (ORCID: https://orcid.org/0000-0002-0660-9162)
- Shiqi Ye (ORCID: https://orcid.org/0009-0007-9070-443X)
- Zhongyuan Wang (ORCID: https://orcid.org/0009-0002-8553-5727)
- Jianfeng Yang (ORCID: https://orcid.org/0000-0002-9526-2438)
- Siqi Zhou (ORCID: https://orcid.org/0009-0000-5436-1256)
- Xiaojian Qin
Institutions
- Fudan University Shanghai Cancer Center (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai Cancer Institute (CN)
- Inner Mongolia People's Hospital (CN)
Publication Details
- Journal
- Journal of the National Cancer Center
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1016/j.jncc.2025.06.003
- Citations
- 7
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 7.32