Longitudinal Changes in Brain Diffusion Characteristics Associated With Cognition and Vascular Risk Factors
Deterioration in microstructural integrity-reflected by lower FA in the left cingulum bundle and higher MD in the left hippocampus-was associated with declines in executive function, language, and memory. Furthermore, longitudinal changes in these FA and MD values had differences based on the presence of type 2 diabetes and smoking. These findings provide a foundational basis for future research to determine whether managing vascular risk factors can delay cognitive decline by affecting the microstructural integrity of the brain.
Authors
- Kenichi Oishi (ORCID: https://orcid.org/0000-0002-1200-8611)
- B. Gwen Windham (ORCID: https://orcid.org/0000-0001-6240-5044)
- Bruce A. Wasserman (ORCID: https://orcid.org/0000-0001-8458-1778)
- Anna Kucharska‐Newton (ORCID: https://orcid.org/0000-0001-9864-467X)
- Kengo Onda (ORCID: https://orcid.org/0000-0002-3346-144X)
- Kei Nishimaki (ORCID: https://orcid.org/0009-0000-7475-9667)
- Yuto Uchida (ORCID: https://orcid.org/0000-0002-6521-0784)
Institutions
- University of North Carolina at Chapel Hill (US)
- University of Maryland, Baltimore (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- University of Mississippi Medical Center (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- Department of Health (ZA)
Publication Details
- Journal
- Neurology
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1212/wnl.0000000000213867
- Citations
- 9
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 12.24