Utility of microbial cell-free DNA sequencing in the diagnosis of mycobacterial infections in a quaternary care center
We examine the performance of microbial cell-free DNA (mcfDNA) next-generation sequencing (NGS) testing on patients admitted to a quaternary care hospital in Houston, Texas. The test was 75.0% sensitive and 97.8% specific for all mycobacterial infections. mcfDNA NGS results led to adjustments in antimicrobial therapy for seven of nine patients with positive results.
Authors
- Fernando H Centeno (ORCID: https://orcid.org/0000-0003-3122-6830)
- Ahmed M Hamdi
- Todd Michael Lasco (ORCID: https://orcid.org/0000-0002-5405-7067)
- Mayar Al Mohajer (ORCID: https://orcid.org/0000-0002-0333-1070)
Institutions
- Baylor College of Medicine (US)
- St. Luke's Hospital (US)
Publication Details
- Journal
- Antimicrobial Stewardship & Healthcare Epidemiology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1017/ash.2025.10057
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00