<i>In vitro</i> activity of ceftobiprole plus ampicillin against <i>Enterococcus faecalis</i> causing infective endocarditis: phenotypic and genotypic characterization
Ampicillin/ceftobiprole showed comparable in vitro activity to ampicillin/ceftriaxone against EFIE. Mutations in the promoter region of pbp4 could compromise the activity of the double β-lactam therapy. The study of ceftobiprole MIC together with DDST is an easy and useful methodology to detect isolates harbouring these mutations, with no synergism to β-lactam combinations.
Authors
- Guillermo Cuervo (ORCID: https://orcid.org/0000-0002-7075-943X)
- Fé Tubau (ORCID: https://orcid.org/0000-0002-6416-6451)
- Jordi Cámara (ORCID: https://orcid.org/0000-0002-0817-0931)
- Carmen Ardanuy (ORCID: https://orcid.org/0000-0003-0225-607X)
- Aída González-Díaz (ORCID: https://orcid.org/0000-0002-8326-1307)
- Dàmaris Berbel (ORCID: https://orcid.org/0000-0002-3689-3360)
- Sara Martí (ORCID: https://orcid.org/0000-0002-0405-2305)
- Francesc Escrihuela-Vidal (ORCID: https://orcid.org/0000-0003-3652-3121)
- M.Á. Domínguez (ORCID: https://orcid.org/0000-0003-3107-9586)
- Clara Moretó-Castellsagué (ORCID: https://orcid.org/0000-0002-1963-4121)
- Sara Calvo-Silveria (ORCID: https://orcid.org/0000-0001-8448-6017)
- Imma Grau (ORCID: https://orcid.org/0000-0003-1014-051X)
Institutions
- Council of Independent Colleges (US)
- Instituto de Salud Carlos III (ES)
- Bellvitge University Hospital (ES)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Barcelona Graduate School of Mathematics (ES)
- Centro de Investigación en Red en Enfermedades Cardiovasculares (ES)
- Hospital Clínic de Barcelona (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1093/jac/dkaf260
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.00