Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis
Our study provides new insights into the molecular mechanisms underlying microglial activation and highlights the therapeutic potential of targeting the mmu-miR-125a/TRAF6 axis to alleviate neuroinflammation by the administration of DEX in POCD.
Authors
- Mu Chen (ORCID: https://orcid.org/0000-0002-7291-0041)
- Zhiyan Xu (ORCID: https://orcid.org/0000-0002-8433-394X)
- Weiyuan Chen (ORCID: https://orcid.org/0000-0003-2727-854X)
- Bin Pan (ORCID: https://orcid.org/0000-0001-8490-7539)
- Kaihua Zhong (ORCID: https://orcid.org/0000-0002-7926-9883)
- Huixia Lan
- Xiaohong Wang (ORCID: https://orcid.org/0000-0001-8628-243X)
- Weifeng Zhong (ORCID: https://orcid.org/0000-0003-4650-176X)
Institutions
- Meizhou City People's Hospital (CN)
- Third Affiliated Hospital of Southern Medical University (CN)
- Precision for Medicine (United States) (US)
- Twelfth Guangzhou City People's Hospital (CN)
- Guangzhou Eighth People's Hospital (CN)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Open Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1515/med-2025-1236
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00