One pot access to 2-iodo-2-deoxy nucleosides directly from glycals and unprotected nucleobases and their biological evaluation on the Japanese Encephalitis Virus
An expedient one-pot stereo- and regioselective synthesis of 2-iodo-nucleosides from protected glycals and nucleobases using easily available iodine and hexamethyldisilane as halogenating, and silylating agents respectively has been developed. Most of the products synthesized characterized as diastereomerically pure β-1,2-trans-diequitorial nucleosides hitherto not reported. The <i>in vitro</i> studies unveil the cogent antiviral activity of these newly synthesized nucleoside derivatives against the Japanese Encephalitis Virus (flavivirus) in the Vero cell line.
Authors
- Ajaz Ahmed
- Debaraj Mukherjee (ORCID: https://orcid.org/0000-0002-2162-7465)
- Norein Sakander (ORCID: https://orcid.org/0009-0002-2143-7204)
- Raj Kamal Tripathi (ORCID: https://orcid.org/0000-0003-3695-1476)
- SK Mishra
- Km. Archana
Institutions
- Bose Institute (IN)
- Central Drug Research Institute (IN)
- Indian Institute of Integrative Medicine (IN)
- Indian Institute of Chemical Technology (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- RSC Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ra02382c
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- Academy of Scientific and Innovative Research
- Science and Engineering Research Board