Multi-omics characterization of diabetic nephropathy in the db/db mouse model of type 2 diabetes
This multi-omics study systematically delineates the molecular landscape of DN pathogenesis, uncovering previously underappreciated metabolic perturbations and distinct lipid dysregulation patterns. Our findings elucidate mechanistic insights into extra-glycemic disease drivers and propose potential therapeutic targets for DN management.
Authors
- Ran Zhou (ORCID: https://orcid.org/0000-0002-8175-2508)
- Junwei Fang (ORCID: https://orcid.org/0000-0002-4303-1750)
- Liping Wang (ORCID: https://orcid.org/0000-0002-2913-311X)
- Yan Li (ORCID: https://orcid.org/0000-0002-3966-1610)
- Xiaodan Zhang (ORCID: https://orcid.org/0000-0001-8621-1113)
- Guanghui Li (ORCID: https://orcid.org/0000-0003-4459-3621)
- Yinchen Shen (ORCID: https://orcid.org/0000-0002-1214-711X)
Institutions
- Eye & ENT Hospital of Fudan University (CN)
Publication Details
- Journal
- Computational and Structural Biotechnology Journal
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.csbj.2025.07.037
- Citations
- 1
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- National Natural Science Foundation of China