The osteoarthritis associated sphingolipid sphingomyelin 34:1 causes inflammatory pain in mice
The results generated demonstrate that a dysregulated lipidome can contribute to inflammatory OA pain, further work being necessary to determine the mechanism by which SM exerts its activity.
Authors
- Ewan St. John Smith (ORCID: https://orcid.org/0000-0002-2699-1979)
- Fraser Welsh
- Luke A. Pattison (ORCID: https://orcid.org/0000-0001-8571-3314)
- Rebecca H. Rickman
- Maya Dannawi (ORCID: https://orcid.org/0000-0002-5457-4654)
- Lanhui Qiu
Institutions
- University of Cambridge (GB)
- Cambridge School (PT)
- AstraZeneca (South Korea) (KR)
- AstraZeneca (Switzerland) (CH)
- AstraZeneca (Spain) (ES)
Publication Details
- Journal
- Osteoarthritis and Cartilage
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1016/j.joca.2025.07.011
- Citations
- 2
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- AstraZeneca
- Wellcome Trust
- UK Research and Innovation
- Versus Arthritis