Hepatic Ketogenesis Regulates Lipid Homeostasis via ACSL1-mediated Fatty Acid Partitioning
Hepatic ketogenesis plays a crucial role in maintaining intracellular acetyl-CoA balance, regulating lipid partitioning, and preventing the development of fasting-induced hepatic steatosis.
Authors
- Fiona M. Bello (ORCID: https://orcid.org/0000-0002-9516-7318)
- Junyan Tao (ORCID: https://orcid.org/0000-0002-5249-970X)
- Karthik Balakrishnan (ORCID: https://orcid.org/0000-0002-4987-8995)
- Michael J. Jurczak (ORCID: https://orcid.org/0000-0002-6335-6915)
- Sadeesh K. Ramakrishnan (ORCID: https://orcid.org/0000-0002-7255-2977)
- Aatur Dilip Singhi (ORCID: https://orcid.org/0000-0003-3930-7096)
- Alison B. Kohan (ORCID: https://orcid.org/0000-0003-3127-7283)
- Evan R. Delgado (ORCID: https://orcid.org/0000-0003-2706-0946)
- Raja Gopal Reddy Mooli
- Jitendra S. Kanshana
- Lihong Teng
- Ericka J. Fiorenza
- Anoop R. Nallanagulagari
- Shreya Karra
- Yerin Han
- Suchita Kumar
Institutions
- University of Pittsburgh (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101593
- Citations
- 2
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
- National Institute of Diabetes and Digestive and Kidney Diseases