Gut microbiota-derived xanthohumol protects against heatstroke by inhibiting macrophage pyroptosis in mice
Our findings suggest that gut microbiota and their associated metabolites play a critical role in heatstroke-induced organ injury. We provide evidence that XN acts as a novel hnRNPK inhibitor, effectively mitigating heatstroke-induced organ injury. Furthermore, gut microbiota-derived XN alleviates heatstroke-induced organ injury by suppressing hnRNPK-dependent macrophage pyroptosis, thereby identifying XN as a promising preventive strategy for heatstroke.
Authors
- Hanhui Zhong
- Yaping Ling
- Qiaobing Huang
- Zhongqing Chen (ORCID: https://orcid.org/0000-0003-2482-949X)
- Hui Chen (ORCID: https://orcid.org/0000-0002-1313-8995)
- Qiang Ma (ORCID: https://orcid.org/0000-0002-2249-7180)
- Yanan Liu (ORCID: https://orcid.org/0000-0003-2290-5380)
- Haixia Liu (ORCID: https://orcid.org/0000-0001-7267-2824)
- Wei Huang (ORCID: https://orcid.org/0000-0002-4217-1567)
- Weidang Xie
Institutions
- Guangdong Medical College (CN)
- Nanfang Hospital (CN)
- Zhujiang Hospital (CN)
- Affiliated Hospital of Guangdong Medical College Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1016/j.jare.2025.07.031
- Citations
- 1
- Primary Topic
- Hops Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.56
Funders
- Innovative Research Group Project of the National Natural Science Foundation of China
- National Natural Science Foundation of China
- Guangdong Medical Research Foundation
- Basic and Applied Basic Research Foundation of Guangdong Province