Probing the therapeutic window of proton minibeam radiotherapy using dose-response curves in a mouse model
We present a comparison method to quantify the efficacy of pMBRT. The observed reduction in acute normal tissue toxicity for pMBRT, compared to conventional proton therapy for at the same PTV dose and maintaining similar tumor control, suggests that pMBRT may offer a substantial therapeutic gain.
Authors
- Line Kristensen (ORCID: https://orcid.org/0000-0003-0924-475X)
- Fardous Reaz (ORCID: https://orcid.org/0009-0002-8332-9655)
- Niels Bassler (ORCID: https://orcid.org/0000-0002-4160-1078)
- Brita Singers Sørensen (ORCID: https://orcid.org/0000-0002-3955-4735)
- Erik Tranéus (ORCID: https://orcid.org/0000-0002-1850-7382)
Institutions
- Aarhus University (DK)
- Aarhus University Hospital (DK)
- RaySearch Laboratories (Sweden) (SE)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1016/j.radonc.2025.111050
- Citations
- 2
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Aarhus Universitet
- Aarhus Universitetshospital
- Novo Nordisk Fonden