Oral Metronomic Formulation of Carboplatin Loaded PEGylated- MWCNTs: HPLC Method Validation and Pharmacokinetic Studies in Rabbit’s Plasma
The developed F2 formulation of carboplatin demonstrates sustained release and improved relative bioavailability following oral administration. It may offer a promising alternative to commercial intravenous CP injections (Kemocarb®), potentially supporting metronomic chemotherapy strategies with improved patient compliance and reduced systemic toxicity.
Authors
- Ketousetuo Kuotsu (ORCID: https://orcid.org/0000-0002-9236-2388)
- Sweet Naskar
- Suraj Sharma (ORCID: https://orcid.org/0000-0002-2705-2148)
Institutions
- Sikkim University (IN)
Publication Details
- Journal
- Current Drug Metabolism
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2174/0113892002378541250704181148
- Primary Topic
- Graphene and Nanomaterials Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00