Newly Described Bacteria Enhances Efficacy of Immune Checkpoint Blockade

Major Finding: The microbiomes of patients that respond to anti–PD-1 are enriched for a newly described bacterial strain, YB328.Concept: YB328 promotes the maturation and migration of CD103+CD11b– cDCs and enhances CD8+ T-cell activation.Impact: This study suggests that YB328, a bacteria present in many human microbiomes, may be leveraged to improve immunotherapy.

Publication Details

Journal
Cancer Discovery
Published
2025-01-01
DOI
https://doi.org/10.1158/2159-8290.cd-rw2025-070
Primary Topic
Cancer Immunotherapy and Biomarkers
Type
article
Field-Weighted Citation Impact
0.00
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article

Newly Described Bacteria Enhances Efficacy of Immune Checkpoint Blockade

Cancer Discovery
Cancer Immunotherapy and Biomarkers
article

Newly Described Bacteria Enhances Efficacy of Immune Checkpoint Blockade

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Abstract

Major Finding: The microbiomes of patients that respond to anti–PD-1 are enriched for a newly described bacterial strain, YB328.Concept: YB328 promotes the maturation and migration of CD103+CD11b– cDCs and enhances CD8+ T-cell activation.Impact: This study suggests that YB328, a bacteria present in many human microbiomes, may be leveraged to improve immunotherapy.

Cancer Discovery
Zero hunger
Openalex Percentile: Top 74%
Cancer Immunotherapy and Biomarkers
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Newly Described Bacteria Enhances Efficacy of Immune Checkpoint Blockade · Cancer Discovery (2025) | TGRS Research Map | TGRS