Formulation and in vitro evaluation of poly-herbal cream containing extracts of curcuma longa and Ocimum tenuiflorum for anti-fungal and anti-inflammatory activities

The skin is a vital organ that plays a crucial role in protecting the body from external factors, regulating body temperature, and aiding in the synthesis of vitamin D. Skin conditions, such as fungal infections and inflammation, are common problems that affect millions of people worldwide. This study focuses on the formulation and evaluation of a dual-action herbal cream that harnesses the potent bioactivities of Curcumin, Curcuma longa and Tulasi, Holy Basil, Ocimum sanctum. The intended outcome is a safe, effective, and well-tolerated topical formulation that offers both antifungal and anti-inflammatory benefits bioactive compound found in turmeric, has anti-inflammatory and antioxidant properties whereas Tulasi, also known as holy basil, has antimicrobial and anti-inflammatory properties. The synergy between Curcumin and Tulasi forms the core of this herbal cream, where their complementary actions target a broad spectrum of pathogenic fungi while simultaneously calming inflammatory responses. The evaluation of this herbal cream involves a comprehensive set of physicochemical and biological tests. Parameters such as pH, viscosity, spread ability, extrudability, and stability under various storage conditions are measured to ensure product quality and shelf-life. Furthermore, in vitro efficacy studies are planned to assess both the antifungal activity by testing against relevant fungal strains and the anti-inflammatory potential, ensuring that the cream meets its therapeutic objectives without inducing skin irritation. This study aims to develop a novel topical product that addresses common skin ailments while minimizing the adverse effects associated with synthetic drugs.