Sex disparity of liver cancer recurrence following surgery: sex-determining region Y gene promotes immunosuppressive microenvironment and favors metastasis
Men are more likely to recur than women after liver resection of liver cancers. SRY promotes immunosuppressive microenvironment in the liver and accounts for male susceptibility of liver cancer recurrence. Targeting SRY-NFκB-CXCL1 axis may have potential value in male-specific surveillance and immunomodulatory therapy of primary liver cancer.
Authors
- Lifang Chen (ORCID: https://orcid.org/0000-0001-9004-8056)
- Jingjing Hou (ORCID: https://orcid.org/0000-0001-9984-9386)
- Timothy Michael Pawlik (ORCID: https://orcid.org/0000-0002-7994-9870)
- Qiang Lü (ORCID: https://orcid.org/0009-0001-9287-8333)
- Jian Dong (ORCID: https://orcid.org/0000-0001-6989-3829)
- Junxi Xiang (ORCID: https://orcid.org/0000-0002-7772-3261)
- Xiao-Ning Wu
- Nan Zhang (ORCID: https://orcid.org/0000-0001-8385-7883)
- Wei Zhang (ORCID: https://orcid.org/0009-0002-3507-4504)
- Xuemin Liu (ORCID: https://orcid.org/0000-0002-4489-9439)
- Fumin Wang (ORCID: https://orcid.org/0000-0003-3693-895X)
- Xu‐Feng Zhang (ORCID: https://orcid.org/0000-0002-4483-7326)
- Feng Xue (ORCID: https://orcid.org/0000-0002-5060-7324)
- Feng Ma (ORCID: https://orcid.org/0000-0001-6443-4885)
- Yi Lisa Lyu
- Yu-Zhu Hou
- Yaoxing Ren
Institutions
- The Ohio State University Wexner Medical Center (US)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-06-30
- DOI
- https://doi.org/10.1097/js9.0000000000002900
- Citations
- 1
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.94