Collaboration among Multiple Large Language Models for Medical Question Answering

Empowered by vast internal knowledge reservoir, the new generation of large language models (LLMs) demonstrate untapped potential to tackle medical tasks. However, there is insufficient effort made towards summoning up a synergic effect from multiple LLMs’ expertise and background. In this study, we propose a multi-LLM collaboration framework tailored on a medical multiple-choice questions dataset. Through post-hoc analysis on 3 pre-trained LLM participants, our framework is proved to boost all LLMs reasoning ability as well as alleviate their divergence among questions. We also measure an LLM’s confidence when it confronts with adversary opinions from other LLMs and observe a concurrence between LLM’s confidence and prediction accuracy.

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Publication Details

Published
2025-06-18
DOI
https://doi.org/10.1109/ichi64645.2025.00052
Citations
1
Primary Topic
Topic Modeling
Type
article
Field-Weighted Citation Impact
2.48

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article

Collaboration among Multiple Large Language Models for Medical Question Answering

Chia‐Hsuan Chang, Christopher C. Yang, Kun Shang
1 citations
Topic Modeling
2.48
article

Collaboration among Multiple Large Language Models for Medical Question Answering

Chia‐Hsuan Chang, Christopher C. Yang, Kun Shang
article en
1 citations

Abstract

Empowered by vast internal knowledge reservoir, the new generation of large language models (LLMs) demonstrate untapped potential to tackle medical tasks. However, there is insufficient effort made towards summoning up a synergic effect from multiple LLMs’ expertise and background. In this study, we propose a multi-LLM collaboration framework tailored on a medical multiple-choice questions dataset. Through post-hoc analysis on 3 pre-trained LLM participants, our framework is proved to boost all LLMs reasoning ability as well as alleviate their divergence among questions. We also measure an LLM’s confidence when it confronts with adversary opinions from other LLMs and observe a concurrence between LLM’s confidence and prediction accuracy.

Drexel University (US)
National Science Foundation
Openalex Percentile: Top 9%
Topic Modeling
2.48
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