Synergies of dibutyl phthalate on high-fat diet can aggravate cardiac fibrosis/dysfunction and the protective effects of vitamin E and salidroside: A molecular toxicological study in Sprague-Dawley rats
This study reveals, for the first time, the synergistic effect of DBP on HFD-induced cardiac fibrosis and dysfunction, suggesting that salidroside has a protective effect against cardiac fibrosis. These findings provide new insights into the multifaceted mechanisms involved in the pathology of cardiac fibrosis induced by DBP and HFD, and offer potential intervention targets for the prevention and treatment of cardiac fibrosis and dysfunction exacerbated by the synergistic effects of DBP and HFD.
Authors
- Deyu Zhu (ORCID: https://orcid.org/0000-0002-2949-9410)
- Yang Wu (ORCID: https://orcid.org/0000-0002-2877-5102)
- Xiao Liang (ORCID: https://orcid.org/0000-0002-1967-1117)
- Qingling Feng (ORCID: https://orcid.org/0000-0003-1288-300X)
- Yang Xu (ORCID: https://orcid.org/0000-0002-0340-1163)
- Qi Huang (ORCID: https://orcid.org/0000-0001-6788-3432)
- Ping Ma (ORCID: https://orcid.org/0000-0002-1172-2805)
- Cuiyu Bao
- Zehong Wei (ORCID: https://orcid.org/0000-0003-0688-1032)
- Xinyu Bao (ORCID: https://orcid.org/0009-0008-8230-349X)
Institutions
- Hubei University of Science and Technology (CN)
Publication Details
- Journal
- Ecotoxicology and Environmental Safety
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1016/j.ecoenv.2025.118708
- Citations
- 3
- Primary Topic
- Medicinal Plants and Bioactive Compounds
- Type
- article
- Field-Weighted Citation Impact
- 2.42