Eradication of MRSA biofilms using amphiphilic cationic coumarin derivatives
Amphiphilic coumarin derivatives have demonstrated potent antibiofilm activity against established methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) biofilms. Scanning electron microscopy (SEM) revealed morphological changes to bacterial cells and eradication of extracellular matrix from established MRSA biofilms when treated with 7-benzyloxy coumarin derivatives.
Authors
- Sally E. Plush (ORCID: https://orcid.org/0000-0002-9999-9154)
- Samuel O. Nitschke (ORCID: https://orcid.org/0000-0002-4455-2056)
- Muhammed Awad (ORCID: https://orcid.org/0000-0002-0402-6406)
- Shane M. Hickey (ORCID: https://orcid.org/0000-0002-3063-531X)
- Nicky Thomas (ORCID: https://orcid.org/0000-0001-8920-1391)
- Ken Neubauer (ORCID: https://orcid.org/0000-0001-7718-7668)
- Gabrielle J. Lowe
- Alysha G. Elliott (ORCID: https://orcid.org/0000-0002-2983-0484)
- Chris Leigh
Institutions
- The University of Queensland (AU)
- University of South Australia (AU)
- Basil Hetzel Institute (AU)
- The University of Adelaide (AU)
Publication Details
- Journal
- RSC Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ra04358a
- Citations
- 1
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 1.18
Funders
- Wellcome Trust
- Australian Government
- University of Adelaide
- University of South Australia
- Department of Education, Australian Governement