OSMI-4-based PROTACs do not influence <i>O</i>-GlcNAc transferase and <i>O</i>-GlcNAcylation levels in cells
The <i>O</i>-GlcNAc transferase (OGT) inhibitors disclosed thus far are burdened with certain shortcomings. We have incorporated OSMI-4, a nanomolar OGT inhibitor, into PROTACs. The prepared chimeras failed to induce effective OGT degradation or influence <i>O</i>-GlcNAcylation levels in MM.1S cells.
Authors
- Lara Smrdel (ORCID: https://orcid.org/0009-0009-5377-6228)
- Izidor Sosič (ORCID: https://orcid.org/0000-0002-3370-4587)
- Marko Anderluh (ORCID: https://orcid.org/0000-0003-1768-8246)
- Doroteja Novak (ORCID: https://orcid.org/0000-0002-6614-263X)
- Aleša Bricelj (ORCID: https://orcid.org/0000-0002-8090-4477)
- Martina Gobec (ORCID: https://orcid.org/0000-0002-9476-601X)
- Christian Steinebach (ORCID: https://orcid.org/0000-0001-5638-1955)
Institutions
- University of Bonn (DE)
- University of Ljubljana (SI)
- Ljubljana University Medical Centre (SI)
Publication Details
- Journal
- RSC Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ra02801a
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Javna Agencija za Raziskovalno Dejavnost RS
- National Institutes of Health
- HORIZON EUROPE Marie Sklodowska-Curie Actions