Muhenrins A–C, pimarane-type diterpenoids from <i>Munronia henryi</i>
Three undescribed pimarane-type diterpenoids, muhenrins A-C (1-3), along with a known analogue were isolated from the petroleum ether extract of <i>Munronia henryi</i> (Meliaceae). Their structures, including absolute configurations, were elucidated by means of various spectroscopic methods (IR, UV, HR-ESI-MS, NMR), single-crystal X-ray diffraction, ECD and NMR calculations. Muhenrin A (1) features a unique 6,7-<i>seco</i> pimarane skeleton, and its putative biosynthetic pathways have been proposed. Compounds 1-4 showed weak inhibitory activity against NO production in LPS-induced RAW 264.7 cells, with inhibition rates ranging from 13.73 - 32.35% at 50 μM concentrations.
Authors
- Yan Li (ORCID: https://orcid.org/0000-0002-1424-3164)
- Yunpeng Sun
- Weihong Su (ORCID: https://orcid.org/0009-0002-7976-9359)
- Xiaomeng Hou (ORCID: https://orcid.org/0000-0002-6793-9085)
- Guo‐Kai Wang (ORCID: https://orcid.org/0000-0002-3924-6169)
- Ling Zhang (ORCID: https://orcid.org/0000-0003-1124-3545)
- Jinsong Liu (ORCID: https://orcid.org/0000-0003-2317-0558)
- Zhipeng Tang (ORCID: https://orcid.org/0000-0001-5695-8072)
- Yang Yu (ORCID: https://orcid.org/0000-0002-9477-2313)
Institutions
- Anhui University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- RSC Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ra04525h
- Primary Topic
- Phytochemical compounds biological activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Key Technologies Research and Development Program of Anhui Province
- National Natural Science Foundation of China
- Anhui University
- State Administration of Traditional Chinese Medicine of the People's Republic of China
- Anhui University of Chinese Medicine