Impact of environmental pollution on human health: Investigating the role of Polycyclic Aromatic Hydrocarbons in pediatric osteosarcoma
This study presents the first systems-level investigation elucidating potential molecular mechanisms linking PAH exposure to pediatric osteosarcoma. The identification of ACTB, EGFR, and JUN as environmentally responsive oncogenic mediators offers a mechanistic framework for future validation. These findings support the utility of computational toxicology in environmental risk assessment and highlight potential molecular targets for the prevention and treatment of pediatric osteosarcoma.
Authors
- Yu Xu (ORCID: https://orcid.org/0000-0003-0014-2298)
- Mingxian Xu (ORCID: https://orcid.org/0000-0003-4580-7804)
- Lifeng Yin (ORCID: https://orcid.org/0000-0002-5181-195X)
- Changye Zou (ORCID: https://orcid.org/0000-0002-2184-6764)
- Jian Qing Shi (ORCID: https://orcid.org/0000-0002-2924-1137)
- Jun-Qiang Yin
- Jian Tu (ORCID: https://orcid.org/0009-0005-3988-3917)
- Yaping Huang
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Ecotoxicology and Environmental Safety
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1016/j.ecoenv.2025.118693
- Citations
- 3
- Primary Topic
- Toxic Organic Pollutants Impact
- Type
- article
- Field-Weighted Citation Impact
- 3.60