Histopathological Evaluation of Liver Tissue Post-Treatment with Hemostatic Agents in Hyperfibrinolysis-Induced Injury: A Comparative Study

Liver trauma complicated by hyperfibrinolysis leads to uncontrolled hemorrhage and systemic coagulopathy, posing significant challenges in clinical management. Objective: To analyze histopathological and clinical changes in hepatic tissue after using hemostatic agents TXA, OCR, and Surgiflo to examine volume of blood loss, duration of blood loss, tissue healing, fibrosis, and inflammation. Methods: A total of 48 rabbits were systematically assigned to four distinct cohorts placing 12 rabbits in each group: Control, Tranexamic Acid (TXA), Oxidized Regenerated Cellulose (ORC), and Surgiflo. Uniform hepatic injuries were surgically induced in all liver specimens. After that, each cohort had the prescribed course of treatment. Time to hemostasis, blood loss volume, D-dimer levels, survival rate, and liver tissue histology were the primary outcomes that were measured. Results: Out of all the groups, Surgiflo had the quickest hemostasis and the least amount of blood loss. The Surgiflo and ORC groups showed better tissue healing, with less fibrosis and mild inflammation, according to histological analysis. The TXA and Control groups, on the other hand, had slower tissue healing and more infiltration of inflammatory cells. Conclusions: Surgiflo was found to be the most successful treatment for liver damage with hyperfibrinolysis based on both clinical and histological results. The outcomes validate its application as a dependable choice for reducing hemorrhage and encouraging tissue repair in cases of complicated liver damage.