KO<sup><i>t</i></sup>Bu-mediated annulation for the pot-economical synthesis of quinazolinobenzoxazepines

A novel and cost-effective KO<sup><i>t</i></sup>Bu-mediated protocol has been developed for synthesizing quinazolinobenzoxazepines from 2-aminobenzonitriles and 2-(2-bromoethoxy)benzaldehydes. This transformation proceeds <i>via</i> a cascade pathway and affords products in moderate to good yields with broad substrate scope and excellent functional group tolerance.

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Publication Details

Journal
Chemical Communications
Published
2025-01-01
DOI
https://doi.org/10.1039/d5cc02401c
Primary Topic
Quinazolinone synthesis and applications
Type
article
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article

KOtBu-mediated annulation for the pot-economical synthesis of quinazolinobenzoxazepines

Jyotirmayee Dash, Soumya Jyoti Basak
1 links
Chemical Communications
Quinazolinone synthesis and applications
article

KOtBu-mediated annulation for the pot-economical synthesis of quinazolinobenzoxazepines

Jyotirmayee Dash, Soumya Jyoti Basak
article en

Abstract

A novel and cost-effective KO<sup><i>t</i></sup>Bu-mediated protocol has been developed for synthesizing quinazolinobenzoxazepines from 2-aminobenzonitriles and 2-(2-bromoethoxy)benzaldehydes. This transformation proceeds <i>via</i> a cascade pathway and affords products in moderate to good yields with broad substrate scope and excellent functional group tolerance.

Chemical CommunicationsVol. 61(67)
Indian Association for the Cultivation of Science (IN)
Openalex Percentile: Top 87%
Quinazolinone synthesis and applications
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KO<sup><i>t</i></sup>Bu-mediated annulation for the pot-economical synthesis of quinazolinobenzoxazepines — Jyotirmayee Dash, Soumya Jyoti Basak · Chemical Communications (2025) | TGRS Research Map | TGRS