How many sites are enough? a novel, site-based power analysis method for real-world registry studies of anti-amyloid monoclonal antibodies
Conventional methods risk underestimating site requirements by ignoring caseload heterogeneity. Our simulation framework provides more realistic estimates and, crucially, quantifies the substantial efficiency gains from strategic recruitment, serving as a flexible tool to optimize registry design.
Authors
- Kenichiro Sato (ORCID: https://orcid.org/0000-0003-4351-9526)
- Yoshiki Niimi (ORCID: https://orcid.org/0000-0002-2556-8167)
- Takeshi Iwatsubo (ORCID: https://orcid.org/0000-0003-1160-8129)
- Ryoko Ihara (ORCID: https://orcid.org/0000-0001-8770-3283)
- Atsushi Iwata (ORCID: https://orcid.org/0000-0001-7308-5314)
Institutions
- University of Tokyo Hospital (JP)
- Tokyo Metropolitan Institute of Gerontology (JP)
- Tokyo Metropolitan Geriatric Hospital (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Journal of Aging Research and Lifestyle
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jarlif.2025.100020
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00