A new strategy for the extrahepatic delivery of lipid-based nanomedicines: a protein corona-mediated selective targeting system based on an ionizable cationic lipid library
Applying a molecularly diverse lipid library in the formulation of LNPs recruits endogenous proteins to generate a customized protein corona that directs LNPs to various extrahepatic organs, eliminating the need for external targeting ligands.
Authors
- Mahmoud A. Younis (ORCID: https://orcid.org/0000-0001-9722-3267)
- Hideyoshi Harashima (ORCID: https://orcid.org/0000-0002-1568-9547)
- Seigo Kimura (ORCID: https://orcid.org/0000-0001-6382-6908)
- Yusuke Sato (ORCID: https://orcid.org/0000-0003-0913-7815)
Institutions
- Hokkaido University (JP)
- Nagoya University (JP)
- Assiut University (EG)
Publication Details
- Journal
- RSC Pharmaceutics
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5pm00079c
- Citations
- 5
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- Japan Agency for Medical Research and Development
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science