Green Synthesis of Terminalia arjuna-mediated Zinc Oxide Nanogel for Enhanced Wound Healing—An In Vitro Study

IntroductIonChronic periodontitis, a severe form of gingival disease affecting a significant portion of the population, is characterized by the accumulation of dental plaque and calculus, leading to inflammation, tissue injury, and eventual loss of alveolar bone that supports teeth.Nearly 62% of dentate individuals were projected to have periodontitis by 2020, with an additional 23.6% suffering from severe periodontitis. 1 The primary pathogen, Porphyromonas gingivalis (P.gingivalis), triggers immune responses that damage gingival tissues and cause bone resorption. 2 Nanotechnology emerges as an innovative solution for periodontitis treatment, offering the potential to reduce plaque and address the underlying inflammatory processes, providing new avenues for more effective and targeted therapeutic interventions in periodontal care. 3inc oxide nanoparticles (ZnONPs) are renowned for their antibacterial properties, positioning them as promising candidates for applications in periodontal care.The antimicrobial activity of ZnONPs, attributed to the presence of zinc ions, has demonstrated efficacy against bacteria associated with periodontitis. 4 This specific property can be harnessed to develop nanoantibacterial agents that selectively target and eliminate harmful bacteria, offering a potential solution without causing systemic toxicity. 5One strategic